Longitudinal changes in theurinary extracellular domain of neurotrophin receptor p75 predict the severity and survival time in amyotrophic lateral sclerosis
- VernacularTitle:尿液p75NTR胞外段变化率对肌萎缩侧索硬化症患者病情严重程度及生存时间的预测
- Author:
Rui JIA
1
;
Ronghua ZHANG
;
Li XUE
;
Jiaoting JIN
;
Fangfang HU
;
Xiao LIU
;
Yonghui DANG
;
Jingxia DANG
Author Information
- Publication Type:Journal Article
- Keywords: amyotrophic lateral sclerosis(ALS); urine; extracellular domain of neurotrophin receptor p75(p75ECD); biomarker; prediction
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2025;46(2):298-303
- CountryChina
- Language:Chinese
- Abstract: Objective To evaluate the ability of longitudinal changes in urinary extracellular domain of neurotrophin receptor p75(p75ECD)to serve as a prognostic biomarker of severity,progression and survival time in patients with amyotrophic lateral sclerosis(ALS).Methods Forty patients with ALS attended follow-up appointments at 3-to 6-month interval,and 51 healthy control(HC)volunteers were recruited.The concentrations of urinary p75ECD were tested by a sandwich ELISA.The ALSFRS-r was used to quantify the severity of ALS.The change rate of urinary p75ECD(Δp75ECD)was calculated as the average monthly change during the period between the first and the last sampling.Results The concentration of urinary p75ECD was higher at the last follow-up than at baseline(P=0.002 3).Spearman analysis showed that there was a negative correlation between urinary p75ECD and ALSFRS-r score(r=-0.35,P=0.001 3);the course of ALS in the fast-changing Δp75ECD group was shorter than that in the slow-changing group(P=0.015 8);the Δp75ECD and course of ALS showed a negative correlation(r=-0.39,P=0.014),and the Δp75ECD in the fast-progression ALS group was significantly higher than in the slow-progression group(P=0.001 6).There was a positive correlation between Δp75ECD and progression in ALS patients(r=0.34,P=0.005).Kaplan-Meier survival analysis showed a longer median survival time in those with slow-changing Δp75ECD(P=0.03).Conclusion The change rate of urinary p75ECD has shown great potential as a biomarker for the prognosis of the severity,progression and survival time of ALS.
