Research Progress on Prevention and Treatment of Alcoholic Liver Disease Based on Organ Crosstalk Theory
10.11842/wst.20240604003
- VernacularTitle:基于器官串扰理论探讨酒精性肝病防治的研究进展
- Author:
Limin DONG
1
;
Ping WANG
;
Yi WANG
;
Xiaodong YAO
;
Zhiping DING
;
Ru ZHANG
Author Information
1. 山东中医药大学药学院 济南 250355
- Publication Type:Journal Article
- Keywords:
Alcoholic liver disease;
Inter-organ cross-talk;
Zangxiang theory
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(6):1522-1529
- CountryChina
- Language:Chinese
-
Abstract:
Alcoholic liver disease(ALD)is a liver disease caused by long-term heavy drinking and one of the most common causes of liver-related morbidity and mortality.According to Chinese medicine,the development of ALD is mainly related to alcoholism,and the evolution of its pathology is a gradually aggravating process.Wine-heat injures the liver,without obvious organic lesions at the initial stage,and as the disease progresses to different stages,internal dampness appears,dampness depresses and transforms into heat,and Qi stagnation and blood stasis are gradually aggravated,which affects the functions of various internal organs,directly or indirectly,and creates a complex mechanism of crosstalk between the liver and other organs,which leads to the pathological condition of This leads to the pathological state of multi-organ dysfunction.Modern research has found that long-term alcohol abuse not only causes direct damage to the liver,but also leads to progression to end-stage liver disease by altering the intestinal barrier function and intestinal microbial community,and producing kidney damage and cardiac function.This article reviewed recent studies on the interactions between the liver and other organs in light of the Chinese and Western pathogenesis of alcoholic liver disease and the theory of organ crosstalk,and introduces potential strategies for the treatment of alcoholic liver disease,which will provide a reference for the discovery of new therapeutic avenues.
