Association Between Triglyceride-glucose Index and Risk of Nonalcoholic Fatty Liver Disease in Young and Middle-aged Adults
10.3969/j.issn.1000-3614.2025.03.011
- VernacularTitle:甘油三酯-葡萄糖指数与中青年人群非酒精性脂肪性肝病发病风险的关联
- Author:
Zheng WU
1
;
Qi QI
;
Xinyu WU
;
Jie YU
;
Bo YANG
;
Xuechao ZHANG
;
Quanle HAN
;
Nan WANG
;
Shouling WU
;
Kangbo LI
Author Information
1. 唐山市工人医院 肝胆外科,唐山 063000
- Publication Type:Journal Article
- Keywords:
triglyceride-glucose index;
young and middle-aged people;
non-alcoholic fatty liver disease;
metabolic syndrome;
insulin resistance
- From:
Chinese Circulation Journal
2025;40(3):277-283
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the association between the triglyceride-glucose(TyG)index and risk of non-alcoholic fatty liver disease(NAFLD)in young and middle-aged(<60 years)adults.Methods:From June 2006 to October 2007,47 675 employees of Kailuan Group with no liver disease were selected as the study objects.Based on the TyG index quartile,participants were divided into Q1 group(TyG index≤8.08,n=11 924),Q2 group(8.0836.46,n=11 919),the association between TyG index,cum-TyG and cumulative exposure time and the risk of NAFLD was analyzed.Results:The average age of the study population was(44.3±8.7)years,36 345 participants were males(76.23%).During a median follow-up period of 11.55(7.28,13.89)years,4 635(9.72%)participants developed new-onset NAFLD.After adjusting for confounders,cox regression analysis showed that compared with the Q1 group,the HR(95%CI)for NAFLD in the Q2 to Q4 groups were 1.328(1.191-1.480),1.591(1.430-1.770),and 2.106(1.861-2.384),respectively,Ptrend<0.001.Compared with the cum-Q1 group,the HR(95%CI)for NAFLD in the cum-Q2 to cum-Q4 groups were 1.571(1.426-1.730),2.123(1.935-2.330)and 2.593(2.367-2.840),respectively,Ptrend<0.001.Compared with the TyG index for 0 year,the HR(95%CI)of NAFLD for 2,4 and 6 years was 1.333(1.196-1.486),1.879(1.690-2.088)and 3.184(2.860-3.545),respectively,Ptrend<0.001.Conclusions:Increased TyG index is an independent risk factor for the new-onset NAFLD in young and middle-aged population.
