Research on Combination of Mitochondrial Oxidative Phosphorylation and Traditional Chinese Medicine in Cardiovascular Diseases
- VernacularTitle:线粒体氧化磷酸化结合中医药在心血管疾病中的研究
- Author:
Ludan ZHANG
1
;
Xinlu WANG
;
Mingjun ZHU
;
Qifei ZHAO
Author Information
- Publication Type:Journal Article
- Keywords: Mitochondrial oxidative phosphorylation; Cardiovascular disease; Energy metabolism; Traditional Chinese medicine
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(6):1786-1794
- CountryChina
- Language:Chinese
- Abstract: Mitochondria are widely involved in the important pathophysiological processes such as cell apoptosis,metabolism,immune response,and signal transduction,and are the central hub of energy metabolism in most eukaryotic cells.Oxidative phosphorylation(OXPHOS)is a key link in mitochondrial adenosine triphosphate(ATP)production for energy supply.Mitochondria provide potential energy through an electron transport chain,which generates a proton gradient in the mitochondrial inner membrane and reacts with complex ATPase to produce ATP.Ischemia,hypoxia,and other factors can cause mitochondrial damage,imbalance of OXPHOS,leading to myocardial energy deficiency,oxidative stress damage,cell apoptosis,and other important mechanisms in the occurrence and development of cardiovascular diseases.Traditional Chinese medicine has a definite therapeutic effect on improving cardiovascular diseases,and its mechanism may be closely related to regulating mitochondrial OXPHOS and reducing structural and functional damage to myocardial cells.Based on this,the mechanism of mitochondrial OXPHOS in cardiovascular diseases and the intervention effect of traditional Chinese medicine were systematically reviewed to provide a basis for clinical treatment of cardiovascular diseases.
