Correlation Analysis Between Epicardial Adipose Tissue and Left Ventricular Remodeling and Myocardial Fibrosis in Patients With Heart Failure With Reduced Ejection Fraction
10.3969/j.issn.1000-3614.2025.03.004
- VernacularTitle:射血分数降低的心力衰竭患者心外膜脂肪组织与左心室重构和心肌纤维化的相关性分析
- Author:
Qingye ZHU
1
;
Didi WEN
;
Minwen ZHENG
Author Information
1. 延安大学延安医学院 放射影像系,延安 716000;中国人民解放军空军军医大学第一附属医院 放射科,西安 710032
- Publication Type:Journal Article
- Keywords:
heart failure;
epicardial adipose tissue;
pericoronary adipose tissue;
left ventricular remodeling;
myocardial fibrosis
- From:
Chinese Circulation Journal
2025;40(3):227-233
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the relationship between epicardial adipose tissue(EAT)(including pericoronary adipose tissue[PCAT])with left ventricular remodeling and myocardial fibrosis in heart failure with reduced ejection fraction(HFrEF)patients.Methods:Consecutive patients diagnosed with HFrEF who underwent coronary computed tomography angiography(CCTA)and cardiac magnetic resonance imaging(CMR)examination at the First Affiliated Hospital of Air Force Medical University between May 2021 and January 2024 were included in this study(n=34).EAT CT attenuation,volume and PCAT CT attenuation of left anterior descending artery(LAD)and right coronary artery(RCA)were measured based on CCTA images.Left ventricular function parameters,late gadolinium enhancement(LGE),and extracellular volume(ECV)were evaluated based on CMR images.The correlations between EAT and PCAT with ventricular remodeling and myocardial fibrosis were evaluated in patients with HFrEF using Spearman analysis.Results:Spearman analysis showed that EAT volume were positively correlated with left ventricular end diastolic volume(LVEDV),left ventricular stroke volume(LVSV)and LGE(all P<0.05).EAT CT attenuation were positively correlated with LVEDV and left ventricular end systolic volume(LVESV),and negatively correlated with left ventricular remodeling index(LVRI),left ventricular ejection fraction(LVEF),left ventricular cardiac output(LVCO)and LGE(all P<0.05).LAD PCAT CT attenuation was positively correlated with LVESV,and negatively correlated with left ventricular maximal wall thickness,LVSV,LVEF,LVCO and LGE(all P<0.05).RCA PCAT CT attenuation were positively correlated with LVEDV and LVESV,and negatively correlated with LVEF and LGE(all P<0.05).EAT CT attenuation,volume and PCAT CT attenuation were not significantly correlated with ECV(all P>0.05).Conclusions:In HFrEF patients,both EAT and PCAT were associated with left ventricular remodeling and myocardial fibrosis.
