Recent research progress into the role of long non-coding RNAs in the molecular mechanism of pulmonary hypertension
10.3969/j.issn.1671-7856.2025.01.015
- VernacularTitle:lncRNA在肺动脉高压分子机制中的最新研究进展
- Author:
Daoxiong WU
1
;
Yanjin LI
;
Ying HU
;
Yuming WANG
;
Wei HU
;
Run MA
Author Information
1. 昆明医科大学第二附属医院检验科,昆明 650106
- Publication Type:Journal Article
- Keywords:
lncRNA;
pulmonary hypertension;
molecular mechanism
- From:
Chinese Journal of Comparative Medicine
2025;35(1):147-154
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary hypertension(PH)is a fatal disease characterized by pulmonary vascular remodeling,ultimately leading to right heart failure and death.Current treatments for PH are suboptimal,with no substantial improvement in overall survival among patients with advanced PH.Despite some progress in understanding the pathogenesis of PH,further studies at the molecular level are needed to develop more effective treatments for PH.Recent research has shown that long non-coding RNAs(lncRNAs)have an important regulatory function in the pathophysiological process of PH,and may thus be potential disease biomarkers and therapeutic targets.In this paper,we review recent progress in our understanding of the molecular mechanisms of lncRNAs in PH.
