The role of targeting ferroptosis in cancer radiotherapy
10.3760/cma.j.cn113030-20241008-00385
- VernacularTitle:靶向铁死亡在肿瘤放射治疗中的研究进展
- Author:
Jingyuan ZHU
1
;
Jinyi LANG
;
Meihua CHEN
Author Information
1. 电子科技大学医学院，成都 611731
- Publication Type:Journal Article
- Keywords:
Ferroptosis;
Radiotherapy;
Targeting ferroptosis;
Radiosensitivity;
Radiation resistance
- From:
Chinese Journal of Radiation Oncology
2025;34(10):1053-1058
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis, an iron-dependent cell death pathway, characterized by iron accumulation and lipid peroxidation, has emerged as a recent discovery. Radiotherapy, utilizing targeted ionizing radiation, stands as a prevalent cancer treatment modality. Recent investigations have unveiled a pronounced interconnection between targeting ferroptosis and radiotherapy. In this article, key molecular mechanisms of ferroptosis and related drugs were systematically summarized, the interaction between ferroptosis and radiotherapy was discussed, and the potential of targeting ferroptosis in enhancing anti-tumor effect mediated by radiotherapy was evaluated, aiming to provide important reference for formulating effective precise radiotherapy strategies.
