Effect of hypofractionated radiotherapy on the function of dendritic cells
10.3760/cma.j.cn113030-20250112-00024
- VernacularTitle:大分割放射治疗对树突状细胞功能的影响
- Author:
Siyi YANG
1
;
Ningbo LIU
1
Author Information
1. 天津医科大学肿瘤医院放疗科，国家恶性肿瘤临床医学研究中心，天津市恶性肿瘤临床医学研究中心，天津市肿瘤防治重点实验室，天津 300060
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
Hypofractionated radiotherapy;
Dendritic cell
- From:
Chinese Journal of Radiation Oncology
2025;34(10):1047-1052
- CountryChina
- Language:Chinese
-
Abstract:
Dendritic cell (DC), as pivotal antigen-presenting cells within the immune system, plays a critical role in overcoming immunosuppression and eliciting tumor-specific immune responses. Hypofractionated radiotherapy, as a distinct form of radiotherapy, not only shortens the treatment duration and improves local tumor control, but also profoundly modulates the tumor microenvironment through immune regulation. Nevertheless, the impact of hypofractionated radiotherapy on the functionality of DC remains incompletely understood. In this article, the effects of hypofractionated radiotherapy on DC survival, phenotypic characteristics, antigen-presenting capacity, migratory ability, cytokine secretion, and T-cell activation were systematically investigated to deepen the understanding of the interplay between hypofractionated radiotherapy and immune system. These findings are anticipated to provide a scientific foundation for optimizing immune modulation strategies in tumor radiotherapy, thereby offering enhanced clinical guidance and improving therapeutic outcomes.
