Progress in the application of hypofractionated thoracic radiotherapy in limited-stage small cell lung cancer
10.3760/cma.j.cn113030-20240825-00324
- VernacularTitle:低分割胸部放疗在局限期小细胞肺癌中的应用进展
- Author:
Jinbiao XU
1
;
Feng QIU
1
Author Information
1. 南昌大学第一附属医院高新医院肿瘤科，南昌 330000
- Publication Type:Journal Article
- Keywords:
Small cell lung carcinoma;
Limited-stage;
Hypofractionated thoracic radiotherapy;
Dose fractionation
- From:
Chinese Journal of Radiation Oncology
2025;34(10):1033-1038
- CountryChina
- Language:Chinese
-
Abstract:
Dose fractionation of thoracic radiotherapy is a hot topic in the study of limited-stage small cell lung cancer. As a dose fractionation mode, hypofractionated thoracic radiotherapy increases the irradiation dose of each session and decreases the total irradiation sessions. It has been explored in a large number of studies, including hypofractionated thoracic radiotherapy dose escalation studies, hypofractionated and hyperfractionated comparative studies, hypofractionated and conventionally-fractionated comparative studies. Under the condition of modern chemoradiotherapy technology, compared with conventionally-fractionated and hyperfractionated protocols, hypofractionated thoracic radiotherapy has advantages in clinical application, biology and immune combination. In addition, hypofractionated thoracic radiotherapy with higher dose shows better efficacy and high safety, which may be a viable alternative to thoracic radiotherapy for limited-stage small cell lung cancer. In this article, current status and future development direction of hypofractionated thoracic radiotherapy for limited-stage small cell lung cancer were discussed.
