Mechanism of copper homeostasis-cuprotosis in osteoarticular diseases and potential applications targeting cuprotosis
10.3969/j.issn.1000-4718.2025.06.022
- VernacularTitle:铜稳态-铜死亡在骨关节疾病中的作用机制及靶向铜死亡的潜在应用
- Author:
Xianjun ZHANG
1
;
Xiaoping WANG
;
Mingwang ZHOU
;
Yongqiang ZHAO
Author Information
1. 甘肃中医药大学中医临床学院,甘肃 兰州 730000
- Publication Type:Journal Article
- Keywords:
copper homeostasis;
cuproptosis;
osteoarthritis;
rheumatoid arthritis;
osteosarcoma
- From:
Chinese Journal of Pathophysiology
2025;41(6):1235-1241
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarticular diseases,common chronic degenerative disorders in the elderly,involve the gradual deterioration and degeneration of bones or joints.The metabolic capacity declines with age.Impaired bone metabolism dis-rupts homeostasis,leading to osteoarticular dysfunctions.Cuprotosis,a novel form of programmed cell death mediated by ferredoxin 1,matters for the pathologic process in osteoarticular diseases.Cuprotosis influences the levels of intercellular signal transduction to induce oxidative stress,inflammation,pyroptosis,and ferroptosis in joints.Those cell death and mi-tochondrial dysfunction ultimately exacerbate the progression of osteoarticular diseases.Therefore,this review summarizes the mechanism of copper homeostasis-cuprotosis in osteoarticular diseases and the potential applications targeting copper homeostasis-cuprotosis.
