Influencing Factors,Potential Mechanisms and Clinical Significance of Cardiac Troponin Elevation Induced by Long-distance Endurance Exercise
10.3969/j.issn.1000-3614.2025.03.015
- VernacularTitle:长距离耐力运动诱导心肌肌钙蛋白升高的影响因素、潜在机制及临床意义
- Author:
Xinyang SONG
1
;
Fang WANG
1
Author Information
1. 北京大学第五临床医学院,北京 100730;北京医院 心内科 国家老年医学中心 中国医学科学院老年医学研究院,北京 100730
- Publication Type:Journal Article
- Keywords:
troponin;
exercise;
marathon
- From:
Chinese Circulation Journal
2025;40(3):297-301
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac troponin(cTn)is the preferred biomarker for the evaluation of myocardial injury.High levels of cTn are associated with the risk of cardiovascular events in both patients and the general population.Although regular exercise improves cardiovascular function,prolonged strenuous exercise can lead to a dramatic increase in cTn concentrations,even above the upper limit of the reference value.There has been controversy on the topic of whether exercise-induced cTn elevations are attributable to physiologic or pathologic conditions,and to date,such elevations have usually been considered as a benign phenomenon.However,recent research suggests that exercise-induced cTn elevation may be viewed as an early biomarker of future cardiovascular events.In order to better understand the diagnostic value of cTn in the exercise cardiovascular field,this article reviews recent research evidences on the factors,underlying mechanisms and clinical significance of cTn elevation induced by long-distance endurance exercise such as marathon.
