Research Progress on Chemical Composition and Pharmacological Effects of Sinopodophyllum hexandrum and Predictive Analysis on Q-marker
10.11842/wst.20241009005
- VernacularTitle:桃儿七化学成分和药理作用研究进展及质量标志物的预测分析
- Author:
Yan LEI
1
;
Yuzhuo LI
;
Wanying WANG
;
Lu SU
;
Jiao KONG
;
Ding LI
;
Hongyan JIA
;
Chuanxin LIU
Author Information
1. 山西医科大学第一医院 太原 030001
- Publication Type:Journal Article
- Keywords:
Sinopodophyllum hexandrum(Royle)T.S.Ying;
Podophyllotoxin;
Podophyllotoxone;
Pharmacological action;
Quality marker(Q-marker);
Constitution-based toxicology
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(6):1555-1577
- CountryChina
- Language:Chinese
-
Abstract:
Sinopodophyllum hexandruma is a traditional Chinese medicine in China,which is mostly distributed in Gansu,Shaanxi,Sichuan,Qinghai,Yunnan and Xizang,etc.In recent years,with the gradual deepening of the research on the chemical composition and pharmacology-toxicology of Sinopodophyllum hexandruma,its antitumour and antiviral pharmacodynamic evaluation has increasingly become a research hotspot in the industry.Based on the chemical structure,pharmacological properties and the theoretical basis of quality markers(Q-markers),this paper presents an in-depth literature review and analysis of the chemical composition,pharmacological activities and Q-markers of Sinopodophyllum hexandruma,and systematically explores and predicts the Q-markers of Sinopodophyllum hexandruma.It is proposed that Podophyllotoxin,picropodophyllotoxin,podophyllotoxinone,quercetin,kaempferol,quercetin-3-O-β-glucoside can be used as the Q-marker of Sinopodophyllum hexandruma.In the later stage,these index components can be selected to control the whole quality of Sinopodophyllum hexandrum,and provide some data support and theoretical reference for the quality evaluation of Sinopodophyllum hexandrum.
