Research progress in radiation-induced rectal injury
10.3760/cma.j.cn113030-20241206-00468
- VernacularTitle:放射性直肠损伤的研究进展
- Author:
Jiawen GUO
1
;
Ye ZHANG
;
Jinbo YUE
;
Wencheng ZHANG
;
Qifeng WANG
;
Pei YANG
;
Hongyun SHI
Author Information
1. 河北大学附属医院放疗科，保定 071000
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Radiotherapy;
Radiation injury;
Research progress
- From:
Chinese Journal of Radiation Oncology
2025;34(9):882-889
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced rectal injury (RRI) refers to inflammatory intestinal complications of patients with pelvic cavity, abdominal cavity and retroperitoneal tumor during or after radiotherapy, presenting symptoms such as diarrhea, abdominal pain, anal distension, bloody stool, etc. In severe cases, rectovaginal fistula, intestinal obstruction, canceration can occur, adversely affecting the quality of life of patients. The clinical factors of RRI involve total radiotherapy dose, tumor volume, radiotherapy mode and patient-related risk factors. The diagnosis mainly depends on imaging examinations (such as CT, MRI and ultrasound), endoscopy and laboratory examination. The mechanism of RRI is related to intestinal epithelial cell destruction, stem cell injury, microvascular changes and microbial flora imbalance. At present, there is no gold standard for RRI treatment, and the main measures include surgical treatment, internal medicine treatment, hyperbaric oxygen therapy and fecal microbiota transplantation, etc. In this article, the latest progress in the pathogenesis, diagnosis and treatment of RRI was reviewed.
