Value of 18F-fluorodeoxyglucose PET/CT in differentiating benign and malignant lymphadenopathy in children,adolescents,and young adults
10.3969/j.issn.1002-1671.2025.06.033
- VernacularTitle:18氟-氟代脱氧葡萄糖PET/CT显像对鉴别儿童、青少年及年轻人淋巴结肿大病变良恶性的价值
- Author:
Ping CHEN
1
;
Qiufen MAO
1
;
Yan ZHENG
1
;
Jiaxin WU
1
;
Cheng HUANG
1
Author Information
1. 河南科技大学第一附属医院核医学科,河南 洛阳 471000
- Publication Type:Journal Article
- Keywords:
children;
adolescent;
young adult;
lymphadenopathy;
positron emission tomography/computed tomography
- From:
Journal of Practical Radiology
2025;41(6):1047-1050
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the value of 18F-fluorodeoxyglucose(18F-FDG)PET/CT in differentiating benign and malignant lymphadenopathy in children,adolescents,and young adults.Methods The clinical and 18F-FDG PET/CT data of 40 children,adolescent and young adult patients with lymphadenopathy as the initial diagnosis who underwent 18F-FDG PET/CT were retrospectively collected.The imaging features and parameters of 18F-FDG PET/CT were analyzed,and receiver operating characteristic(ROC)curves were plotted to evaluate its diagnostic value.Results Of the 40 patients,21 had malignant lymphadenopathy and 19 had benign lymphadenopathy.18F-FDG PET/CT showed that the distribution of lymph nodes in the body was mainly divided into the following two categories:widespread/scattered distribution or localized distribution.However,mediastinal lymph nodes in the benign patients were usually not or less involved.In addition,the maximum diameter and maximum short diameter of malignant lymph nodes were significantly higher than those of benign(Z=-4.189,-4.190,all P＜0.001),while there was no statistically significant difference in the maximum standardized uptake value(SUVmax)(Z=-1.882,P＞0.05).ROC curve analysis showed that the best cutoff values of the maximum diameter and maximum short diameter of lymph nodes for differentiating benign and malignant lymphadenopathy were 24.5 mm and 16.5 mm,with the area under the curve(AUC)of both 0.887,sensitivities of 95.2％and 90.5％,and specificities of 78.9％and 73.7％,respectively.Conclusion The distribution characteristics of lymph nodes on 18F-FDG PET/CT,as well as the maximum diameter and maximum short diameter of lymph nodes in imaging parameters,are helpful in distinguishing benign and malignant lymphadenopathy in children,adolescents,and young adults.
