Current applications of RadScopal technology in cancer therapy
10.3760/cma.j.cn113030-20250309-00092
- VernacularTitle:RadScopal技术在肿瘤治疗中的应用现状
- Author:
Yang ZHOU
1
;
Ximei ZHANG
;
Xiangpan LI
Author Information
1. 三峡大学肿瘤微环境与免疫治疗湖北省重点实验室，宜昌 443002
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Radiotherapy;
Immunotherapy;
Low-dose;
High-dose
- From:
Chinese Journal of Radiation Oncology
2025;34(12):1251-1256
- CountryChina
- Language:Chinese
-
Abstract:
With the discovery of programmed cell death protein 1 (PD-1) and its ligand (PD-L1), the crucial role of the immune microenvironment in tumor therapy has been increasingly recognized. In recent years, as research on the interaction between ionizing radiation and the immune system has deepened, low-dose radiotherapy (LDRT) has emerged, based on the concept that LDRT can alleviate the immunosuppressive state of the tumor microenvironment. High-dose radiotherapy (HDRT), on the other hand, can kill in-situ tumors and thus release more tumor antigens. Therefore, combining HDRT with LDRT and integrating it with immunotherapy-collectively known as the "radiotherapy-induced scopal effect" (RadScopal)-has become a promising new therapeutic approach. This review summarizes the mechanisms and clinical studies of this mixed-dose irradiation strategy, aiming to provide a detailed theoretical basis and reference for the clinical application of RadScopal technology.
