Advances in the role and mechanisms of proton beam therapy in tumor immune modulation
10.3760/cma.j.cn113030-20241208-00471
- VernacularTitle:质子束放疗在肿瘤免疫调节中的作用与机制研究进展
- Author:
Yarui CHEN
1
;
Ziying DAI
1
;
Hongxin SU
1
;
Juntao RAN
1
Author Information
1. 兰州大学第一医院放疗科，兰州 730000
- Publication Type:Journal Article
- Keywords:
Proton therapy;
Tumor immune modulation;
Immunogenic cell death;
Tumor microenvironment;
Immune checkpoint inhibitors
- From:
Chinese Journal of Radiation Oncology
2025;34(12):1245-1250
- CountryChina
- Language:Chinese
-
Abstract:
The role of radiotherapy in activating antitumor immune responses has attracted growing attention. Proton beam therapy (PBT), owing to its unique physical and biological properties, holds great potential in cancer immunotherapy. PBT not only directly kills tumor cells but also induces immunogenic cell death, remodels the tumor microenvironment, and modulates immune cell functions. Moreover, PBT shows distinct advantages in inducing systemic immune responses and establishing immune memory. Recent studies have demonstrated that PBT offers unique benefits over conventional photon radiotherapy in activating antitumor immunity and exhibits marked synergistic effects when combined with immune checkpoint inhibitors (ICIs). This review systematically summarizes recent advances in understanding the role and mechanisms of PBT in tumor immune modulation, discusses the prospects of its combination with immunotherapy, and provides new insights and theoretical evidence for comprehensive cancer treatment.
