Research progress and clinical application prospects of proton arc therapy

VernacularTitle:质子弧形治疗的研究进展与临床应用前景
Author: Mohan ZHOU ¹ ; Xianliang WANG ¹ ; Xufeng GAO ¹ ; Pei WANG ¹ ; Feng YANG ¹ ; Xin XIN ¹ ; Wei YING ¹
Author Information

1. 四川省肿瘤临床医学研究中心，四川省肿瘤医院·研究所，四川省癌症防治中心，电子科技大学附属肿瘤医院放疗科，成都　610041
Publication Type:Journal Article
Keywords: Proton therapy; Proton arc therapy; Clinical applications; Biological effects
From: Chinese Journal of Radiation Oncology 2025;34(11):1165-1170
CountryChina
Language:Chinese
Abstract: Proton arc therapy (PAT), as an emerging radiation therapy technique, has attracted increasing widespread attention in the field of cancer radiotherapy in recent years. In this review, technological developments, clinical application potential, biological effects, dosimetric optimization, and current challenges of PAT were comprehensively summarized. A systematic analysis of recent studies indicates that PAT offers significant advantages in improving target coverage and sparing normal tissues, particularly in mitigating organ motion-induced uncertainties. However, PAT remains in the clinical validation stage and still faces challenges related to technical optimization and cost control. Further clinical studies are required to confirm its long-term efficacy and safety.