Analysis of clinical features and prognosis in pediatric malignant solid tumors of head and neck in single-center
10.3969/j.issn.1006-7795.2025.03.020
- VernacularTitle:单中心儿童头颈部恶性实体肿瘤临床特征及预后分析
- Author:
Peiyi YANG
1
;
Chao DUAN
;
Shengcai WANG
;
Mei JIN
;
Dawei ZHANG
;
Libing FU
;
Tong YU
;
Zhikai LIU
;
Xiaoli MA
;
Xin NI
;
Yan SU
Author Information
1. 国家儿童医学中心,首都医科大学附属北京儿童医院,儿童肿瘤中心,肿瘤内科,儿童肿瘤国家临床重点专科,首都医科大学基础-临床联合实验室/儿童肿瘤发病机制与创新药物研究实验室,儿科重大疾病研究教育部重点实验室,北京 100045
- Publication Type:Journal Article
- Keywords:
head and neck;
malignant solid tumor;
children;
clinical features;
prognosis
- From:
Journal of Capital Medical University
2025;46(3):545-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the clinical features and prognosis of children suffered from malignant solid tumors of head and neck.Methods The clinical data of children with primary malignant solid tumors located in the head and neck was retrospectively analyzed from January 2007 to December 2021 in the Department of Oncology,Beijing Children's Hospital,Capital Medical University,and the clinical features,prognostic factors were summarized.Results A total of 234 children with malignant solid tumors of head and neck were included,with a male to female ratio of 1∶0.7,aged from 3 months to 17 years and 6 months(median age 51 months).173 cases(73.9％)were treated with local painless masses.Other symptoms included snoring and facial paralysis.The proportion of rhabdomyosarcoma(RMS)was the highest(145 cases,62.0％),followed by neuroblastoma(NB)(25 cases,10.7％),Ewing sarcoma(19 cases,8.1％),etc.A total of 47 cases(20.1％)had distant metastasis.The patients received surgery,chemotherapy and radiotherapy under the mode of multidisciplinary treatment(MDT).The 3-year and 5-year overall survival(OS)were 80.8％and 75.8％,respectively,and the 3-year and 5-year progression free survival(PFS)were 64.0％and 58.9％,respectively.Tumor survivors had abnormal appearance or facial motor function(49 cases,41.2％),developmental problems or abnormal tooth loss(18 cases,15.1％),and other long-term complications that may be related to the tumor or treatment.Conclusion There are various pathologic types of pediatric head and neck malignant solid tumors,RMS and NB are the most common.Local painless mass was the most common complaint.Distant metastasis is an independent risk factor for the prognosis of head and neck malignant solid tumors.Under the MDT model,the prognosis of malignant solid tumors of the head and neck in our center was generally good.In the treatment of the tumors,the side effects and sequelae should be controlled as small as possible under the premise of long-term survival.
