Advances in moderate-hypofractionated post-prostatectomy radiotherapy
10.3760/cma.j.cn113030-20240729-00292
- VernacularTitle:前列腺癌术后中等大分割放疗的研究进展
- Author:
Yiyin LIANG
1
;
Xin CHEN
1
;
Xianzhi ZHAO
1
;
Weiwei ZHANG
1
;
Bichun XU
1
;
Huojun ZHANG
1
Author Information
1. 海军军医大学第一附属医院（上海长海医院）放射治疗科，上海 200433
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Radical prostatectomy;
Hypofractionated radiotherapy;
Post-prostatectomy radiotherapy
- From:
Chinese Journal of Radiation Oncology
2025;34(11):1159-1164
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is the second most common malignancy among men worldwide. Owing to its unique biological characteristics (a low α/β ratio), hypofractionated radiotherapy can improve tumor control in prostate cancer. Consequently, the American National Comprehensive Cancer Network (NCCN) guidelines have recommended hypofractionated radiotherapy as the preferred treatment option for localized prostate cancer. However, the use of hypofractionated radiotherapy in pelvic irradiation after radical prostatectomy remains limited, and its safety and efficacy are yet to be fully established. Investigating the feasibility of moderate-hypofractionated post-prostatectomy radiotherapy has therefore become a recent focus of clinical research. In this review, moderate-hypofractionated post-prostatectomy radiotherapy was categorized according to the per-fraction dose and current evidence was summarized from retrospective studies, prospective studies, and ongoing clinical trials.
