The correlation between carotid plaque parameters of dual-energy CT angiography and the occurrence of acute stroke events
10.3969/j.issn.1002-1671.2025.06.004
- VernacularTitle:双能量CT血管成像颈动脉斑块参数与急性脑卒中事件发生的相关性
- Author:
He ZHANG
1
;
Juan LONG
;
Dexing ZHOU
;
Pan YU
;
Xuefu XIA
;
Cong SONG
;
Yong WANG
;
He ZHANG
;
Lili ZHU
;
Chunfeng HU
;
Kai XU
;
Yankai MENG
Author Information
1. 徐州医科大学附属医院医学影像科,江苏 徐州 221002;徐州医科大学医学影像学院,江苏 徐州 221002;徐州市贾汪区人民医院医学影像科,江苏 徐州 221011
- Publication Type:Journal Article
- Keywords:
acute cerebral infarction;
dual-energy CT;
computed tomography angiography;
carotid plaque;
intraplaque hemorrhage
- From:
Journal of Practical Radiology
2025;41(6):910-914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between dual-energy computed tomography angiography(CTA)parameters of carotid plaques and acute stroke events.Methods A retrospective analysis was conducted on the clinical and imaging data of patients who underwent dual-energy head and neck CTA and brain MRI scans.Utilizing the Siemens workstation(Syngo.Via VB40B),region of interest(ROI)were placed on the thickest slice of the carotid plaque in the axial plane to obtain parameters such as fat fraction(FF),virtual non-contrast(VNC)value,iodine concentration(IC),electron density(Rho),effective atomic number(Zeff),dual energy index(DEI),spectral curve,and corresponding CT values at 40 keV(40 keVHU)and 90 keV(90 keVHU).The slope of the energy spectrum curve(λ)was calculated within the 40 keV-90 keV range.Patients with acute cerebral infarction(ACI)in the ipsilateral anterior circulation territory were classified into the ACI group,while those without were classified into the non-acute cerebral infarction(NACI)(NACI group).Qualitative data were analyzed using the x2 test,and quantitative data were analyzed using the t-test.The predictive performance was assessed using the area under the curve(AUC)of the receiver operating characteristic(ROC)curve,and the differences between different ROC curves were compared using the DeLong test.Results A total of 72 patients were included,with 21 in the ACI group and 51 in the NACI group.The mean values of FF,Zeff,and 40 keVHU in the ACI group were greater than those in the NACI group.Statistically significant differences were observed between the groups for Zeff,DEI,40 keVHU,and λ(P＜0.05).40 keVHU demonstrated the highest predictive performance,and the AUC,sensitivity,and specificity was 0.789,81.0％,and 74.5％,respectively.A combined variable constructed through logistic regression analysis yielded an AUC,sensitivity,and specificity of 0.796,85.7％,and 70.6％,respectively,with no significant statistical differences compared to single factor variables.Conclusion Dual-energy CTA parameters of carotid plaques may aid in predicting intraplaque hemorrhage(IPH)and the occurrence of acute stroke events.
