Analysis of the correlation between perivascular space changes on MRI and cognition in patients with subacute ischemic stroke
10.3969/j.issn.1002-1671.2025.06.002
- VernacularTitle:基于MRI的血管周围间隙变化与亚急性缺血性卒中患者认知的相关性分析
- Author:
Yanqiang QIAO
1
;
Yue QIN
;
Huili ZOU
;
Liyao LIU
;
Juan TIAN
;
Ruirui LIU
;
Ming ZHANG
Author Information
1. 西安交通大学第一附属医院影像科,陕西 西安 710061;西安大兴医院影像科,陕西 西安 710082
- Publication Type:Journal Article
- Keywords:
perivascular space;
ischemic stroke;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2025;41(6):900-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes of perivascular space(PVS)in patients with subacute ischemic stroke(IS),as well as the relationship between PVS and cognitive dysfunction in IS patients,and to analyze the relationship between PVS indicators and cognitive function in subacute IS patients of different ages.Methods A total of 44 healthy controls(HC)and 39 patients with subacute IS were prospectively included.Automated quantitative analysis of MRI data was conducted to determine pPVS in the white matter and subcortical regions.Differences in pPVS between patients with subacute IS and HC were compared.Correlations between age,pPVS,and cognitive dysfunction were analyzed and modeled.Results Compared with the HC,the white matter pPVS in patients with subacute IS was significantly reduced(t=-2.21,P=0.031).In patients with subacute IS,the white matter pPVS showed a significant positive correlation with lesion volume(r=0.42,P=0.030)and mini-mental state examination(MMSE)scores(r=0.44,P=0.018).Both white matter pPVS(r=-0.42,P=0.010)and MMSE scores(r=-3.82,P=0.000 7)were negatively correlated with age.When age was over 61.35 years,there was a positive correlation between the white matter pPVS and MMSE scores.Conclusion PVS are closely related to cognitive impairment in patients with subacute IS.Age is a significant modulating factor in the relationship between PVS and cognitive dysfunction.Early monitoring of PVS and targeting it for intervention may positively impact the improvement of cognitive dysfunction following IS.
