Differentiation and treatment of lung cancer with cardiovascular disease comorbidity
10.3969/j.issn.1006-2157.2025.06.015
- VernacularTitle:肺癌共病心血管疾病的辨治
- Author:
Lingling SUN
1
;
Yiying LYU
;
Duo LI
;
Yinshuang LIU
;
Lizhu LIN
Author Information
1. 广州中医药大学 广州 510405;广州中医药大学第一附属医院;广东省中医临床研究院
- Publication Type:Journal Article
- Keywords:
lung cancer;
cardiovascular disease;
heart-lung correlation theory;
reciprocal regulation of heart-lung
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(6):839-844
- CountryChina
- Language:Chinese
-
Abstract:
Originating in Huangdi Neijing,this theory was pioneered by ZHANG Zhongjing,who established the principles of concurrent heart-lung treatment and integrated therapeutic approaches.It further developed during the Ming-Qing period and has been widely applied in modern clinical practice.This article systematically traces the developmental trajectory of the heart-lung correlation theory in traditional Chinese medicine and analyzes its clinical application in elucidating the pathogenesis and therapeutic strategies for lung cancer complicated by cardiovascular comorbidities.According to this theoretical framework,lung cancer accompanied by cardiovascular comorbidities exhibits a pathomechanism characterized by fundamental deficiency with symptomatic excess.The deficiency manifests as qi-blood depletion or impaired descent of gathering qi,while the excess is reflected in phlegm-stasis coagulation or heat-toxin accumulation.Key pathological features include progressive transformation,meridian disharmony,deteriorating vital substances,and disruption of inter-organ relationships.Treatment adheres to the principles of concurrent heart-lung intervention,integrated cardiopulmonary modulation,and reciprocal organ regulation.Core therapeutic strategies involve eliminating pathogenic factors,promoting circulation,tonifying deficiencies,and harmonizing functions with specific interventions determined through pattern differentiation.For the pattern of phlegm and blood stasis coagulation affecting both the heart and lung,treatment is guided by the principle of simultaneous treatment of phlegm and stasis,coordinated regulation of heart-lung function,and prioritization of qi circulation.Commonly used formulas include Gualou Xiebai Banxia Decoction and Xuefu Zhuyu Decoction.In cases of heat toxin accumulation in the heart and lungs,therapy follows the principle of clearing heart-lung fire and dredging collaterals,often using combinations of insect-derived medicines and vine-derived herbs,such as earthworm and Chinese star jasmine stem.In instances of heart-lung qi-blood deficiency,the therapeutic approach emphasizes simultaneous fortification and qi and blood circulation.Formulas such as modified Renshen Yangrong Decoction or Shengxian Decoction,combined with Taohong Siwu Decoction,are commonly used.These formulas strengthen qi without stagnating blood,promote blood circulation without harming healthy qi,and gradually eliminate pathogens.These three treatment approaches embody the characteristics of integrated heart-lung therapy,emphasizing dynamic regulation and holistic concepts.The focus remains on addressing both manifestation and root causes through flexible herb selection to achieve optimal therapeutic outcomes.
