Prediction of microvascular invasion and its risk classification in hepatocellular carcinoma by nomograms of Gd-EOB-DTPA enhanced MRI
10.3969/j.issn.1002-1671.2025.06.018
- VernacularTitle:钆塞酸二钠增强MRI列线图预测肝细胞癌微血管侵犯及危险分级
- Author:
Cunzhong MENG
1
;
Fan ZHAO
1
Author Information
1. 武威市人民医院CT/MRI中心,甘肃 武威 733000
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
microvascular invasion;
risk classification;
gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid;
magnetic resonance imaging;
nomogram
- From:
Journal of Practical Radiology
2025;41(6):979-983
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a prediction model for microvascular invasion(MVI)and its risk classification in hepatocellular carcinoma(HCC)based on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid(Gd-EOB-DTPA)enhanced MRI.Methods Patients who underwent preoperative MRI examination and surgical pathological confirmation of HCC were included.The patients were divided into MVI-negative(M0),MVI-low-risk(M1)and MVI-high-risk(M2)groups,and their clinical data,laboratory test results and MRI signs were compared.Univariate and multivariate logistic regression analyses were used to determine the independent risk factors for MVI and high-risk MVI,and the nomograms for predicting MVI and high-risk MVI were established based on the logistic regression analysis results.Results Significant differences in alpha-fetoprotein(AFP),pathological grade,tumor diameter,tumor margin,peri-tumoral enhancement in arterial phase and peri-tumoral hypo-intensity in hepatobiliary phase were observed among the three groups.Logistic regression analysis showed that larger tumor diameter,non-smooth tumor margin and peri-tumoral hypo-intensity in hepatobiliary phase were independent risk factors for predicting high-risk MVI(P＜0.05),meanwhile the above factors,as well as AFP≥400 ng/mL and peri-tumoral enhancement in arterial phase,were associated with the occurrence of MVI(P＜0.05).The predicted MVI and high-risk MVI nomograms were developed based on the above factors,and the C-index was 0.838 and 0.764,respectively.Conclusion Gd-EOB-DTPA enhanced MRI signs are correlated with the status and classification of MVI,and nomograms developed on the basis of the above features is helpful to predict the individual's risk of MVI before surgery.
