The relationship between CT and MRI findings of thymus tumors and immunohistochemical expressions of Ki-67 and p63
10.3969/j.issn.1002-1671.2025.06.010
- VernacularTitle:胸腺肿瘤的CT、MRI表现与免疫组化Ki-67、p63表达的关系
- Author:
Yanman ZHANG
1
;
Qing ZHANG
1
Author Information
1. 南通大学附属医院医学影像科,江苏 南通 226001
- Publication Type:Journal Article
- Keywords:
thymus tumor;
computed tomography;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2025;41(6):938-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between CT and MRI findings of thymus tumors and the expressions of Ki-67 and p63 in immunohistochemistry.Methods A total of 99 patients with thymus tumors were examined by CT and MRI to analyze the features of CT and MRI and the expressions of Ki-67 and p63 in cancer tissues of patients with different signs.Results The positive rates of Ki-67 and p63 in patients with thymus tumors were 61.62％and 64.65％,respectively.The positive rate of Ki-67 in patients with burr sign and lobulation sign was higher than that in those without signs(P＜0.05).The positive rate of p63 in patients with fuzzy lesion boundaries and burr sign was higher than those with clear lesion boundaries and without burr sign(P＜0.05).The positive rate of Ki-67 in patients with uneven enhancement signal and enlarged lymph nodes was higher than that in patients with uniform enhancement signal and without abnormal lymph nodes(P＜0.05).The positive rate of p63 in patients with uneven enhancement signal and chest metastasis was higher than that in patients with uniform enhancement signal and without chest metastasis(P＜0.05).By binary logistic regression analysis,burr sign,lobulation sign,uneven enhancement signal and enlarged lymph nodes could be the related factors of Ki-67 positive expression in thymus tumors patients.Burr sign,fuzzy lesion boundaries,uneven enhancement signal,and chest metastasis were correlated with p63 positive expression in patients with thymus tumors(P＜0.05).Conclusion The CT and MRI signs of thymus tumors are correlated with the expressions of Ki-67 and p63 in tumor tissue.
