Longitudinal changes of thalamic metabolites assessed by hydrogen proton MR spectroscopy in patients of cervical spondylotic myelopathy following decompression surgery
10.3969/j.issn.1002-1671.2025.06.003
- VernacularTitle:脊髓型颈椎病患者减压术后丘脑代谢产物纵向变化的氢质子MR波谱研究
- Author:
Jiangqin ZHENG
1
;
Xiaonan TIAN
;
Ning WANG
;
Baogen ZHAO
;
Ting GAO
;
Yong WANG
;
Li ZHANG
Author Information
1. 河北医科大学医学影像学院,河北 石家庄 050000
- Publication Type:Journal Article
- Keywords:
cervical spondylotic myelopathy;
magnetic resonance spectroscopy;
thalamus;
modified Japanese Orthopaedic Association score
- From:
Journal of Practical Radiology
2025;41(6):904-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective To access the changes of thalamic metabolites before and 6 months after surgery in patients with cervical spondylotic myelopathy(CSM)using hydrogen proton magnetic resonance spectroscopy(1H-MRS)and to analyze its association with improvement in neurological function.Methods Forty-eight CSM patients(CSM group)who underwent cervical decompression surgery were included,and 33 healthy controls(HC)(HC group)were recruited.All subjects underwent bilateral thalamic 1H-MRS scans before the surgical procedure,and subsequently again 6 months later.Neurological function was assessed pre-operatively and post-operatively(6 months)in all patients with CSM using the modified Japanese Orthopaedic Association(mJOA)score.The changes of mJOA(△mJOA)were employed as an indicator of neurological improvement.The pre-and post-operative thalamic metabolites ratio of N-acetyl aspartate/creatine(NAA/Cr),choline/Cr(Cho/Cr),myo-inositol/Cr(mI/Cr),glutamate and glutamine/Cr(Glx/Cr)were compared in CSM patients and HC.A correlation analysis was conducted to determine the relationship between alterations in pre-and post-operative thalamic metabolites ratio(△NAA/Cr,△Cho/Cr,△mI/Cr,△Glx/Cr)and △mJOA.Results Compared to HC group,patients with CSM group showed significantly lower NAA/Cr(t=-4.988,P＜0.001;t=-3.562,P=0.001),Cho/Cr(t=-5.946,P＜0.001;t=-2.764,P=0.007)and mI/Cr(t=-3.988,P＜0.001;t=-2.079,P=0.041)before and 6 months after surgery.6 months post-operative NAA/Cr(t=-2.805,P=0.007)and mI/Cr(t=-3.285,P=0.003)were increased in CSM groups compared to pre-operative NAA/Cr and mI/Cr.In CSM group,△mI/Cr correlated significantly with △mJOA(r=0.478 2,P=0.000 6).Conclusion There are differences in thalamic metabolites in CSM patients before and after surgery.△mI/Cr is correlated with the improvement of neurological function,which can be used as an imaging parameter to evaluate the neurological function recovery in patients with CSM after surgery.
