Research progress on the role and potential mechanism of butyrate in the prevention and treatment of diabetic kidney disease
10.3969/j.issn.1006-6187.2025.11.014
- VernacularTitle:丁酸盐在糖尿病肾脏疾病防治中的作用及潜在机制的研究进展
- Author:
Yukun LIU
1
;
Xi CHENG
1
;
Wei HUANG
1
Author Information
1. 646000 泸州,西南医科大学附属医院内分泌与代谢内科
- Publication Type:Journal Article
- Keywords:
Butyrate;
Diabetic kidney disease;
Inflammation;
Fibrosis;
Epigenetics
- From:
Chinese Journal of Diabetes
2025;33(11):871-874
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease(DKD)is the main cause of end-stage renal disease and the main burden of the health care system.The current understanding of the mechanism of DKD progression recognizes the involvement of oxidative stress,low-grade inflammation,and fibrosis.This article reviews the protective effect of dietary fiber on DKD and its potential molecular mechanism through intestinal flora metabolites-butyric acid and butyrate,in order to provide a new strategy for the prevention and treatment of DKD.
