Expression of insulin-like growth factor family 2 in bladder cancer and its relationship with survival and prognosis
10.3969/j.issn.1009-8291.2025.11.011
- VernacularTitle:胰岛素样生长因子家族2在膀胱癌中的表达及其与患者生存预后的关系
- Author:
Yi DING
1
;
Wenbo HUANG
1
;
Zhiyang LIU
1
;
Guangui FENG
1
Author Information
1. 九江学院第二附属医院泌尿外科,江西九江 332005
- Publication Type:Journal Article
- Keywords:
IGFL2;
bladder cancer;
prognosis;
immune infiltration;
immune checkpoint;
bioinformatics
- From:
Journal of Modern Urology
2025;30(11):975-982
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prognostic value and immune effects of insulin-like growth factor family 2(IGFL2)in bladder cancer based on data from TCGA,TIMER2.0 and HPA.Methods Bioinformatics analysis was conducted to analyze the expression of IGFL2 in bladder cancer and its relationship with survival and prognosis of bladder cancer patients.The receiver operating characteristic(ROC)curve and prognostic nomogram were plotted to analyze the diagnostic value of IGFL2 for bladder cancer and its ability to predict the 5-year overall survival rate of patients.IGFL2-related signaling pathways were analyzed with GSEA enrichment.The correlation between IGFL2 expression and immune cells was analyzed based on data from the TIMER database.Results IGFL2 was highly expressed in bladder cancer(P＜0.001).The high expression of IGFL2 was positively correlated with patients'age,pathological stage,histological grade and T stage(all P＜0.05).Patients'with high IGFL2 expression had shorter overall survival and disease-specific survival than those with low IGFL2 expression(all P＜0.05).IGFL2 could be used as an independent prognostic factor for bladder cancer with good diagnostic and predictive value.GSEA enrichment analysis showed that IGFL2 was involved in signaling pathways related to immunity,inflammation and tumor.High IGFL2 expression was positively correlated with the infiltration of most immune cells.Conclusion IGFL2 is highly expressed in bladder cancer and can be a biomarker for the diagnosis and prognosis of this disease.It may become a potential target for immunotherapy.
