Trends in drug resistance of Mycobacterium tuberculosis at a hospital in Xiamen: a 10-year analysis (2015-2024)
10.3760/cma.j.issn.1674-2397.2025.03.004
- VernacularTitle:厦门市某医院2015至2024年结核分枝杆菌耐药分析
- Author:
Yinghui YANG
1
;
Dinghui WU
;
Weicong2 REN
;
Yuxiang CHEN
;
Yu2 PANG
;
Xiangyang YAO
Author Information
1. 厦门市杏林医院肺科，厦门 361022
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
Drug resistance;
Multidrug-resistant tuberculosis;
Fluoroquinolones;
Drug resistance trends
- From:
Chinese Journal of Clinical Infectious Diseases
2025;18(3):193-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the drug resistance status of Mycobacterium tuberculosis（MTB）at a hospital in Xiamen over the past decade. Methods:Sputum culture-positive specimens of tuberculosis patients from Xiamen Xinglin Hospital from 2015 to 2024 were collected retrospectively. Isolates were identified as MTB complex and subjected to drug susceptibility testing. Drug resistance patterns and trends over the study period were analyzed using descriptive statistics and Chi-square trend tests in SPSS 27.0 and GraphPad Prism 8.0.Results:Among 3 883 MTB isolates analyzed，1 132（29.15%）exhibited resistance to at least one drug. The highest rates of resistance to individual first-line drugs were observed for isoniazid（INH，16.04%），streptomycin（SM，15.43%），and rifampicin（RFP，12.28%）. Multidrug-resistant tuberculosis（MDR-TB）was identified in 380 isolates（9.79%）. The predominant MDR resistance patterns were INH+RFP+SM（2.34%），INH+RFP（1.65%），and INH+RFP+SM+ethambutol（EMB）（1.03%）. Polyresistance was found in 188 isolates（4.84%），the predominant patterns were INH+SM（1.49%），INH+fluoroquinolone（FQs）（0.31%），and INH+para-aminosalicylic acid（PAS）（0.31%）. Extensively drug-resistant tuberculosis（XDR-TB）was detected in 49 isolates（1.26%）. From 2015 to 2024，significant decreasing trends were observed for overall drug resistance（ χ2=8.858， P=0.003），MDR（ χ2=15.692， P<0.001），and RFP resistance（ χ2=21.627， P<0.001）. In contrast，fluoroquinolone（FQs）resistance showed no significant trend（ χ2=0.149， P=0.699）. Among RFP resistant and MDR isolates，FQs resistance rates were notably high at 33.12%（158/477）and 36.84%（140/380），respectively. Conclusions:The MTB resistance situation in the hospital has gradually declined in the past 10 years，but the resistance situation remains severe，and clinical attention needs to be strengthened on the use of FQs.
