Application of Fresh Herb-Derived Nanovesicles in the Treatment of Virus-Induced Infectious Diseases
10.14148/j.issn.1672-0482.2025.1452
- VernacularTitle:鲜药来源纳米囊泡在病毒感染性疾病治疗中的应用
- Author:
Qiyi LIU
1
;
Shuya ZHUANG
;
Jichuan FU
;
Peng CAO
;
Haoran WANG
Author Information
1. 南京中医药大学 中药制药过程控制与智能制造技术全国重点实验室,江苏 南京 210023
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
fresh herb;
fresh herb-derived nanovesicles;
antiviral infectious disease
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(11):1452-1463
- CountryChina
- Language:Chinese
-
Abstract:
Viruses,as important biological agents influencing human health and social development,have played a key role in the spread of epidemics and the evolution of diseases since ancient times.Upon infecting hosts,viruses often trigger a series of com-plex responses,including innate and adaptive immunity,inflammatory responses and pathological damage.Despite advances in mod-ern antiviral drugs development,chemical drugs typically rely on a single molecular target within the viral life cycle,making them highly susceptible to the emergence of drug resistance and the induction of systemic toxic side effects.In contrast,traditional Chi-nese medicines(TCMs),posing the distinctive advantage of multi-component,multi-target,and multi-pathway,have exerted a pivotal role in viral prevention and viral treatment.In recent years,fresh herbs have gained increasing attention for their ability to preserve intact bioactive components.Fresh herb-derived nanovesicles possess excellent biocompatibility,targeting and cross-species regula-tory capabilities.These fresh herb-derived nanovesicles can effectively encapsulate and deliver a variety of antiviral components,demonstrating significant potential in antiviral immunomodulation,inflammation control and viral-induced pathologies.This review systematically sorts out the mechanisms of viral infection,and summarizes the advantages of fresh herbs,and the application pros-pects of fresh herb-derived nanovesicles in antiviral therapy.Furthermore,it focuses on summarizing the research progress of fresh herb-derived nanovesicles in the field of antiviral therapy,with the aim of providing insights and references for the development of fresh herb-derived nanovesicles-based antiviral strategies,as well as offering novel approaches and perspectives for the clinical treat-ment of viral diseases.
