National bloodstream infection bacterial resistance surveillance report 2023: Gram-positive bacteria
- VernacularTitle:2023年全国血流感染细菌耐药监测报告：革兰阳性菌
- Author:
Chaoqun YING
1
;
Jinru JI
;
Zhiying LIU
;
Qing YANG
;
Haishen KONG
;
Jiangqin SONG
;
Hui DING
;
Yanyan LI
;
Yuanyuan DAI
;
Haifeng MAO
;
Pengpeng TIAN
;
Lu WANG
;
Yongyun LIU
;
Yizheng ZHOU
;
Jiliang WANG
;
Yan JIN
;
Donghong HUANG
;
Hongyun XU
;
Peng ZHANG
;
Xinhua QIANG
;
Hong HE
;
Lin ZHENG
;
Junmin CAO
;
Zhou LIU
;
Ying HUANG
;
Yan GENG
;
Haiquan KANG
;
Dan LIU
;
Guolin LIAO
;
Lixia ZHANG
;
Fenghong CHEN
;
Yanhong LI
;
Baohua ZHANG
;
Haixin DONG
;
Xiaoyan LI
;
Donghua LIU
;
Qiuying ZHANG
;
Xuefei HU
;
Liang GUO
;
Sijin MAN
;
Dijing SONG
;
Rong XU
;
Youdong YIN
;
Kunpeng LIANG
;
Aiyun LI
;
Zhuo LI
;
Hongxia HU
;
Guoping LU
;
Jinhua LIANG
;
Qiang LIU
;
Yinqiao DONG
;
Jilu SHEN
;
Shuyan HU
;
Liang LUAN
;
Jian LI
;
Ling MENG
;
Dengyan QIAO
;
Xiusan XIA
;
Bo QUAN
;
Dahong WANG
;
Chunhua HAN
;
Xiaoping YAN
;
Fei LI
;
Shifu WANG
;
Ping SHEN
;
Yunbo CHEN
;
Yonghong XIAO
Author Information
- Publication Type:Journal Article
- Keywords: Gram-positive bacteria; Bacterial drug resistance; Bloodstream infection; Drug resistance surveillance; Nationwide
- From: Chinese Journal of Clinical Infectious Diseases 2025;18(2):118-132
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To report the nationwide surveillance results of pathogenic profiles and antimicrobial resistance patterns of Gram-positive bloodstream infections in China in 2023.Methods:The clinical isolates of Gram-posttive bacteria from blood cultures were collected in member hospitals of National Bloodstream Infection Bacterial Resistant Investigation Collaborative System（BRICS）during January to December 2023. Antimicrobial susceptibility testing was performed using the dilution method recommended by the Clinical and Laboratory Standards Institute（CLSI）. Statistical analyses were conducted using WHONET 5.6 and SPSS 25.0 software.Results:A total of 4 385 Gram-positive bacterial isolates were obtained from 60 participating center. The top five pathogens were Staphylococcus aureus（ n=1 544，35.2%），coagulase-negative Staphylococci（ n=1 441，32.9%）， Enterococcus faecium（ n=574，13.1%）， Enterococcus faecalis（ n=385，8.8%），and α-hemolytic Streptococci（ n=187，4.3%）. The prevalence of methicillin-resistant Staphylococcus aureus（MRSA）and methicillin-resistant coagulase-negative Staphylococci（MRCNS）was 26.2%（405/1 544）and 69.8%（1 006/1 441），respectively. Notably，all Staphylococci remained susceptible to glycopeptide or daptomycin. Staphylococcus aureus demonstrated excellent susceptibility（>97.0%）to cephalobiol，rifampicin，trimethoprim-sulfamethoxazole，linezolid，minocycline，tigecycline，and eravacycline. No Enterococcus exhibiting resistance to linezolid were detected. Glycopeptide resistance was uncommon but more frequent in Enterococcus faecium（resistance to vancomycin and teicoplanin：both 1.7%）compared to Enterococcus faecalis（both 0.3%）. The detection rates of MRSA and MRCNS exhibited significant regional variations across the country（ χ2=17.674 and 148.650，respectively，both P<0.001）. No vancomycin-resistant Enterococci were detected in central China. Institutional comparison demonstrated higher prevalence of MRSA（ χ2=14.111， P<0.001）and MRCNS（ χ2=4.828， P=0.028）in provincial hospitals than that in municipal hospitals. Socioeconomic analysis identified elevated detection rates of both MRSA（ χ2=18.986， P<0.001）and MRCNS（ χ2=4.477， P=0.034）in less developed regions（per capita GDP
