Abnormal top-down and bottom-up attention patterns in patients suffering from coronary heart disease with heart qi deficiency syndrome
10.3969/j.issn.1006-7795.2025.03.009
- VernacularTitle:冠状动脉粥样硬化性心脏病心气虚证患者自上而下和自下而上注意模式的异常
- Author:
Bixiu HUO
1
;
Hongxiao JIA
1
;
Yanzhe NING
1
;
Sisi ZHENG
1
Author Information
1. 首都医科大学附属北京安定医院国家精神疾病医学中心国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室,北京 100088;人脑保护高精尖创新中心,首都医科大学,北京 100069
- Publication Type:Journal Article
- Keywords:
heart-qi deficiency syndrome;
coronary heart disease;
top-down;
bottom-up;
attention
- From:
Journal of Capital Medical University
2025;46(3):455-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the abnormality of top-down and bottom-up attention patterns in patients suffering from coronary heart disease(CHD)patients with heart-qi deficiency syndrome based on the theory of"five spirits".Methods From July 2024 to December 2024,30 CHD patients with heart-qi deficiency syndrome were recruited,and 30 subjects without CHD as the control group according to the principle of matching age,sex and years of education.Two groups of subjects were tested with top-down and bottom-up spatial cueing paradigm.Results Compared with the control group,CHD patients with heart-qi deficiency syndrome had longer valid reaction time(vRT)and lower average reaction time difference value(△RT)in top-down test(P＜0.05),and longer vSRT in bottom-up test.Correlation analysis showed that heart-qi deficiency syndrome score was positively correlated with top-down test indexes invalid reaction time(ivRT)(P＜0.05),negatively correlated with △RT(P＜0.01)and valid accurany(vAC)(P＜0.05).It was positively correlated with valid long reaction time(vLRT)(P＜0.01)and invalid long reaction time(ivLRT)(P＜0.01).Generalized linear model analysis showed that non-CHD subjects had shorter vRT(P＜0.01)and larger △ RT(P＜0.05)than CHD patients for top-down test.For bottom-up tests,non-CHD subjects had shorter vSRT than CHD patients(P＜0.05).Conclusion The change of top-down and bottom-up attention patterns in CHD patients with heart-qi deficiency syndrome provides a modern neuropsychological basis for the theory of"heart stores spirits".
