Shared Genetic Structure of Alzheimer's Disease and Cardiovascular Disease based on Genomic Structural Equations
10.11783/j.issn.1002-3674.2025.05.010
- VernacularTitle:基于基因组结构方程模型的阿尔茨海默病和心血管疾病的共享遗传结构研究
- Author:
Shuting XUE
1
;
Durong CHEN
;
Liufei DENG
Author Information
1. 山西医科大学公共卫生学院卫生统计学教研室(030001)
- Publication Type:Journal Article
- Keywords:
Genomic structural equation modeling;
Factor analysis;
Alzheimer's disease;
Cardiovascular disease
- From:
Chinese Journal of Health Statistics
2025;42(5):694-698
- CountryChina
- Language:Chinese
-
Abstract:
Objective Genome structural equation modeling(GSEM)was used to study the shared genetic structure between Alzheimer's disease(AD)and eight cardiovascular diseases(CVD).Methods In this study,based on AD and CVD data from large consortia and genome-wide association studies,we used chained unbalanced score regression to assess the genetic correlation between the diseases;GSEM was introduced to cross-validate with exploratory factor analysis at odd chromosomes and validation factor analysis at even chromosomes,and pathway analysis was combined to establish three-factor,cofactor,and bifactorial models,so as to reveal the complex genetic relationships between the diseases.Additionally,a cross-validation was performed by swapping the positions of odd and even chromosomes.Results The nine selected diseases can be explained by a three-factor model consisting of three independent factors;a cofactor model explains the relationship between a cofactor and each disease;and an extended two-factor model(a combination of the three-factor model and the cofactor model)performs best in fitting the study data.Conclusion GSEM can be used to explore the shared genetic structure between AD and CVD to discover their interactions,laying a methodological foundation for understanding the genetic relationship between complex diseases.
