Advances in the role of STAT3 in tumor immunology
10.3969/j.issn.1006-7795.2025.03.007
- VernacularTitle:STAT3在肿瘤免疫应答中的作用机制研究进展
- Author:
Wenxiu ZHANG
1
;
Yang XIONG
1
;
Minghang YU
1
;
Xi WANG
1
Author Information
1. 传染病溯源预警与智能决策全国重点实验室,首都医科大学附属北京地坛医院,北京 100015;首都医科大学附属北京地坛医院传染病研究所,新发突发传染病研究北京市重点实验室,首都医科大学附属北京地坛医院国家传染病医学中心,北京 100015;北京市感染性疾病研究中心,北京 100015;首都医科大学肿瘤学系,北京 100069
- Publication Type:Journal Article
- Keywords:
signal transducer and activator of transcription;
STAT3;
immunology;
tumor immunology;
immunotherapy
- From:
Journal of Capital Medical University
2025;46(3):442-447
- CountryChina
- Language:Chinese
-
Abstract:
Signal transducer and activator of transcription 3(STAT3)are nuclear transcription factors that regulates expression of genes that are involved in cell cycle,cell survival,and cancer-related immune response.Activated STAT3 may participate in oncogenesis by stimulating cell proliferation,resisting apoptosis and promoting tumor angiogenesis and metastasis.Furthermore,abnormal activation of STAT3 is associated with poor tumor prognosis.Recent advances have revealed a crucial role of persistent activation of STAT3 in cancer progression and immune escape.STAT3 is also an important driver of mediated immune escape in tumor immunity,so it has become an effective target in immunotherapy.Therefore,STAT3 became frequently studied targets for more specific cancer immunotherapies.This article elaborated the multiple functions of STAT3 in innate immunity,adaptive immunity and tumor immunity.Further,it put forward to the prospects and issues that urgently need to be addressed in the future.
