Considerations on clinical cure strategies for chronic hepatitis B based on long-acting interferon
10.3760/cma.j.issn.1674-2397.2025.02.009
- VernacularTitle:基于长效干扰素的慢性乙型肝炎临床治愈策略的思考
- Author:
Weixi TANG
1
;
Lingyao DU
1
Author Information
1. 四川大学华西医院感染性疾病中心，成都 610041
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Long-acting interferon;
Clinical cure;
Treatment strategies
- From:
Chinese Journal of Clinical Infectious Diseases
2025;18(2):154-160
- CountryChina
- Language:Chinese
-
Abstract:
Long-acting interferons，as one of the recommended drugs for achieving clinical cure in chronic hepatitis B（CHB），exert significant effects through multiple important mechanisms in the treatment of chronic hepatitis B virus infection since their clinical introduction. These mechanisms include inducing antiviral proteins，immune modulation，and regulation of epigenetic modifications. This article systematically elaborates on the antiviral and immune regulatory mechanisms of long-acting interferon，explores clinical cure strategies and influencing factors based on long-acting interferon，and looks forward to the emerging directions of CHB clinical cure in the future，aiming to provide reference for optimizing CHB clinical treatment strategies and improving efficacy.
