Research advances on the pathogenesis of metabolic dysfunction-associated fatty liver disease in HIV-infected individuals
10.3760/cma.j.issn.1674-2397.2025.02.008
- VernacularTitle:HIV感染合并代谢相关脂肪性肝病的发病机制研究进展
- Author:
Huiting LIU
1
;
Yirui XIE
1
Author Information
1. 传染病重症诊治全国实验室 国家感染性疾病临床医学研究中心 浙江大学医学院附属第一医院感染病科，杭州310003
- Publication Type:Journal Article
- Keywords:
HIV;
Metabolic dysfunction-associated fatty liver disease;
Pathogenesis
- From:
Chinese Journal of Clinical Infectious Diseases
2025;18(2):147-153
- CountryChina
- Language:Chinese
-
Abstract:
With the use of antiretroviral therapy，the life expectancy of people living with human immunodeficiency virus（HIV）has increased，making metabolic non-infectious diseases major comorbidities. Metabolic dysfunction-associated fatty liver disease（MAFLD）is now the most common cause of non-viral liver disease in HIV-infected individuals. Due to its high prevalence and potential severity，MAFLD imposes a serious health. Understanding its pathogenesis is crucial for developing effective prevention and treatment strategies. This review summarizes recent progress on the mechanisms of HIV-associated MAFLD，focusing on gut-liver axis imbalance，chronic inflammation and immune activation，effects of antiretroviral drugs，and genetic susceptibility.
