Effects of different weight-loss regimens on glucose and lipid metabolism and cardiopulmonary function in overweight patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.11.004
- VernacularTitle:不同减重方案对超重2型糖尿病患者糖脂代谢和心肺功能影响的研究
- Author:
Jun LI
1
;
Juan HUANG
1
;
Weiwei LI
1
Author Information
1. 400030 重庆市沙坪坝区人民医院全科医学科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Overweight;
Low carbon ketogenesis diet;
Continuous caloric restriction;
Glucose and lipid metabolism;
Cardiopulmonary function
- From:
Chinese Journal of Diabetes
2025;33(11):816-819
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of continuous caloric restriction(CCR)and low carbon ketogenic diet(LCK)on glucose and lipid metabolism and cardiopulmonary function in overweight patients with type 2 diabetes mellitus(T2DM).Methods In this study,90 patients with T2DM and overweight who received treatment in our hospital from May 2020 to May 2021 were randomly selected as research objects,and 90 patients were randomly divided into control(Con,n=30)group,CCR group(n=30),and LCK group(n=30).After 3 monthes,the body mass index(BMI),changes of blood glucose,blood lipid,heart function and lung function of the three groups were compared.Results After treatment,the BMI,fasting plasma glucose,2-hour postprandial blood glucose,hemoglobin A1c,fasting insulin,insulin resistance index,total cholesterol,triglycerides,low-density lipoprotein cholesterol,average systolic ejection velocity,shortening rate of left ventricular circumference,vital capacity/weight decreased in turn(P<0.05),high-density lipoprotein cholesterol,fasting C-peptide increased in turn(P<0.05).Compared with Con group,the cardiac ejection time,left ventricular ejection fraction,vital capacity and forced expiratory volume in the first second in CCR and LCK groups increased after treatment(P<0.05),while the average systolic ejection rate,left ventricular circumference shortening rate and vital capacity/weight decreased(P<0.05).Conclusions Both CCR and LCK can improve the cardiopulmonary function of overweight T2DM patients,and LCK can improve BMI and glucose and lipid metabolism more effectively.
