Advances in research on host factors for pathogenesis of non-tuberculous mycobacterial disease
10.3760/cma.j.issn.1674-2397.2025.01.005
- VernacularTitle:非结核分枝杆菌病发病的宿主因素研究进展
- Author:
Wenqian ZENG
1
;
Yifan HE
;
Li WANG
;
Wei SHA
Author Information
1. 南昌大学医学部，南昌 330006
- Publication Type:Journal Article
- Keywords:
Non-tuberculous mycobacteria;
NTM disease;
Host factors
- From:
Chinese Journal of Clinical Infectious Diseases
2025;18(1):30-36
- CountryChina
- Language:Chinese
-
Abstract:
In recent years，the incidence and prevalence of non-tuberculous mycobacterial（NTM）infections have been on the rise，posing a serious threat to public health and presenting significant challenges for disease management. Currently，the treatment outcomes for NTM disease are poor，one of the main reasons being the high resistance of NTM pathogens to various anti-mycobacterial drugs. Novel therapeutic strategies targeting the host rather than the NTM pathogens themselves may help improve cure rates and reduce mortality. This article summarizes the latest research findings on host factors related to the incidence of NTM disease，including age，pulmonary diseases，immune function，genetic factors and lifestyle，which aids in the early identification of high-risk populations and provides a theoretical basis for developing targeted prevention and treatment strategies and optimizing treatment plans.
