Research progress in radiotherapy-induced NK cell modulation of tumor microenvironment
10.3760/cma.j.cn113030-20241014-00395
- VernacularTitle:放射治疗通过NK细胞调控肿瘤微环境的研究进展
- Author:
Zhuoya ZHANG
1
;
Huanyu ZHANG
;
Pengcheng ZHANG
;
Tanglong ZHANG
;
Juntao RAN
Author Information
1. 兰州大学第一临床医学院，兰州 730000
- Publication Type:Journal Article
- Keywords:
Tumor microenvironment;
Radiotherapy;
Tumors;
Killer cells, natural;
Immunotherapy
- From:
Chinese Journal of Radiation Oncology
2025;34(6):629-634
- CountryChina
- Language:Chinese
-
Abstract:
Tumor microenvironment plays a key role in oncogenesis, development and therapeutic response. In recent years, scholars at home and abroad have paid more and more attention to the regulation of tumor microenvironment. Radiation therapy, as an important means of tumor treatment, not only kills tumor cells directly, but also affects the efficacy of radiation therapy by influencing natural killer (NK) cells to regulate the tumor microenvironment. In this article, the research progress in the regulation of tumor microenvironment by radiation therapy through NK cells was reviewed, including the mechanism of NK cell regulation by radiation therapy, the functional changes of NK cells in the tumor microenvironment, as well as the therapeutic strategies based on the above mechanism and the potential application prospects, aiming to provide novel ideas for future basic research and clinical applications.
