Impact of body mass index on the perioperative and long-term outcomes of robotic-assisted partial nephrectomy in patients with clear cell renal cell carcinoma
10.3969/j.issn.1009-8291.2025.11.002
- VernacularTitle:身体质量指数对接受机器人辅助肾部分切除术肾透明细胞癌患者围手术期结局及预后的影响
- Author:
Ziyi CHEN
1
;
Wenjin YANG
1
;
Zeqing CHEN
1
;
Hongqian GUO
1
;
Changwei JI
1
Author Information
1. 南京大学医学院附属鼓楼医院泌尿外科,江苏南京 210008
- Publication Type:Journal Article
- Keywords:
body mass index;
clear cell renal cell carcinoma;
robotic-assisted partial nephrectomy;
perioperative period;
long-term follow-up
- From:
Journal of Modern Urology
2025;30(11):918-921,931
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of body mass index(BMI)on the perioperative outcomes and prognosis in patients with clear cell renal cell carcinoma(ccRCC)undergoing robot-assisted partial nephrectomy(RAPN),so as to provide reference for optimizing clinical management strategies.Methods The clinical data of 745 ccRCC patients undergoing RAPN at our hospital during 2014 and 2023 were retrospectively analyzed.Patients were categorized into three groups according to preoperative BMI:normal weight(18＜BMI＜24,n=202),overweight(24＜BMI＜28,n=428),and obese(BMI≥28,n=115).Baseline characteristics,surgical parameters,postoperative complications,pre-and post-operative estimated glomerular filtration rate(eGFR),and overall survival(OS)were compared among the groups.Multivariate regression analyses were performed to adjust potential confounders.Results Among baseline characteristics,only the gender distribution differed significantly among the three groups(P=0.009).Multivariate analysis showed that gender had no significant effects on reoperation,transfusion,operation time,intraoperative blood loss,or postoperative renal function.The median follow-up was 32(12,55)months.Compared with the normal-weight group,the obese group had longer operation time[140.0(115.0,170.0)min vs.160.0(125.0,190.0)min,P=0.009]and greater intraoperative blood loss[50.0(50.0,100.0)mL vs.100.0(50.0,150.0)mL,P=0.003].No statistically significant differences were observed among the three groups in pre-and post-operative eGFR,overall complication rate,long-term follow-up eGFR,or OS(P＞0.05).Conclusion RAPN provides comparable surgical benefits across BMI categories in patients with ccRCC;however,obese patients may experience increased operation time and blood loss.
