A Dose-response Meta-analysis Between Triglyceride-glucose Index and Risk of Stroke
10.3969/j.issn.1000-3614.2025.06.009
- VernacularTitle:甘油三酯-葡萄糖指数与脑卒中发病风险关系的剂量-反应Meta分析
- Author:
Li YOU
1
;
Xinping CHI
;
Yalin ZHOU
;
Chunshan ZHAO
;
Chunli MEI
;
Bowen LIN
Author Information
1. 北华大学 护理学院,吉林 132013
- Publication Type:Journal Article
- Keywords:
stroke;
triglyceride-glucose index;
meta-analysis;
dose-response;
prospective study
- From:
Chinese Circulation Journal
2025;40(6):611-618
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To quantitatively evaluate the relationship between triglyceride-glucose index and stroke risk by a dose-response meta-analysis.Methods:Prospective cohort studies on the association between triglyceride-glucose(TyG)index and stroke risk were searched by computer in China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service Platform,VIP,China Biomedical Literature Database,PubMed,Embase and Web of Science.The retrieval time was from the self-established database to November 7,2024.Two researchers used the Newcastle-Ottawa Scale(NOS)to evaluate literature quality and then extract relevant data for the included literatures.Stata 17.0 software was used for statistical analysis.Results:A total of 17 prospective literatures were included,involving 449 210 subjects,including 28 506 patients with stroke.The results of meta-analysis showed that the TyG index was positively correlated with the risk of stroke(HR=1.60,95%CI:1.45-1.76,P<0.05).The results of dose-response meta-analysis showed that there was a positive correlation between the TyG index and the risk of stroke,and every 1 unit increase of the TyG index,the risk of stroke increased by 20.2%.According to Egger's test,the P value is 0.962,and the P value of Begg's test is 0.967,indicating that there was no publication bias in the literature included in this study.Conclusions:There is a linear dose-response relationship between TyG index and stroke risk,and higher TyG index can increase the risk of stroke.
