Effects of deep hyperthermia on immune function during postoperative adjuvant chemotherapy in patients with colorectal cancer
10.3760/cma.j.cn113030-20240829-00338
- VernacularTitle:深部热疗对结直肠癌患者术后辅助化疗期间免疫功能的影响
- Author:
Lei ZHAO
1
;
Hongbo WANG
;
Wenzhi LIU
;
Feng LIN
;
Jian YU
;
Mingjun SUN
;
Baosheng YU
;
Yunxiao ZHONG
;
Yougang CUI
;
Xu ZHANG
;
Yupeng YI
;
Na WANG
;
Daocheng WU
;
Chenyang LI
;
Pan HU
;
Ning FENG
Author Information
1. 青岛市即墨区人民医院胃肠外科，青岛 266200
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Hyperthermia;
Chemotherapy;
Adverse effects
- From:
Chinese Journal of Radiation Oncology
2025;34(5):461-467
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of deep hyperthermia on chemotherapy-related adverse effects and immune-inflammatory indicators in the patients undergoing postoperative adjuvant chemotherapy for colorectal cancer.Methods:This retrospective study included 52 patients who underwent surgery for colorectal cancer at the Affiliated Zhongshan Hospital of Dalian University from September 2021 to December 2023. The patients were divided into two groups based on treatment method: the combination group ( n=29) received postoperative adjuvant chemotherapy combined with deep hyperthermia, while the chemotherapy group ( n=23) received postoperative adjuvant chemotherapy alone. Both groups were treated with the XELOX regimen (oxaliplatin + capecitabine). The degree of bone marrow suppression during treatment was assessed by analyzing peripheral blood parameters, including hemoglobin, leukocyte count, neutrophil count, and platelet count. Immune-inflammatory indicators, including complement, procalcitonin (PCT), interleukin-6 (IL-6), systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), were compared before and after treatment in both groups to evaluate the effects of deep hyperthermia on the immune-inflammatory response. Chi-square test or Fisher's exact test (two-tailed) was used to compare bone marrow suppression rates, and the immune-inflammatory indicators between the two groups were compared using t-tests or non-parametric tests, depending on whether the data conformed to a normal distribution. Results:In terms of myelosuppression, the incidence rates of moderate to severe decreases in leukocytes, neutrophils, platelets, and hemoglobin in the combination group were 31%, 31%, 21%, and 14%, respectively, compared to 52%, 61%, 48%, and 9% in the chemotherapy group. The change in PCT levels before and after treatment was significantly greater in the combination group than in the chemotherapy group ( P = 0.010). Both the combination group and the chemotherapy group showed significant reductions in SII, NLR and PLR after treatment, and the differences were statistically significant (all P < 0.05). The change in NLR before and after treatment was significantly greater in the combination group than in the chemotherapy group ( P = 0.031). Conclusions:Deep hyperthermia can alleviate chemotherapy-induced adverse effects such as thrombocytopenia and neutropenia in patients undergoing postoperative adjuvant chemotherapy for colorectal cancer. It also appears to improve the inflammatory response in these patients.
