Comparison of the effects of remimazolam and propofol on postoperative nausea and vomiting in patients undergoing extracorporeal pancreatic lithotripsy based on inverse probability weighting method
- VernacularTitle:基于逆概率加权法对比瑞马唑仑与丙泊酚对胰腺体外碎石患者术后恶心呕吐的影响
- Author:
Hailiang DU
1
;
Pingyi SONG
;
Wanxing DUAN
;
Jun CHEN
;
Yangsen ZHOU
;
Dawei LUO
;
Yansong LI
;
Yaomin ZHU
Author Information
- Publication Type:Journal Article
- Keywords: remimazolam; propofol; pancreatic extracorporeal shock wave lithotripsy(P-ESWL); postoperative nausea and vomiting(PONV)
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2025;46(6):985-990
- CountryChina
- Language:Chinese
- Abstract: Objective To compare the effects of remimazolam and propofol on postoperative nausea and vomiting(PONV)after pancreatic extracorporeal shock wave lithotripsy(P-ESWL),with the aim of optimizing the anesthesia regimen for this procedure.Methods Clinical data were retrospectively collected from patients who underwent P-ESWL for pancreatic stones under general anesthesia at The First Affiliated Hospital of Xi'an Jiaotong University from January 2021 to December 2024.A total of 307 patients were recruited,with 103 in the remimazolam group and 204 in the propofol group.Inverse probability of treatment weighting(IPTW)based on propensity scores was used to balance baseline characteristics and confounding factors between the two groups.The incidence of PONV and anesthesia recovery time were compared between the two groups.Results Before IPTW,there were statistically significant differences between the remimazolam and propofol groups in gender[male/female:51/52 vs.155/49],smoking history(27.2％vs.42.6％),intraoperative sufentanil use[25(10)μg vs.30(10)μg],remifentanil use[429.00(177)μg vs.480.50(209)μg],rocuronium use[36(6)mg vs.38(7)mg],and intraoperative dexamethasone use(62.1％vs.49.0％)(all P＜0.05).After IPTW,the baseline characteristics and confounding factors were balanced and comparable between the two groups(P＞0.05).Before IPTW,the incidence of PONV was higher in the remimazolam group than in the propofol group(24.3％vs.14.7％,P=0.039).After IPTW,the two groups did not significantly differ in the incidence of PONV(21.5％vs.17.5％,P=0.215),and the anesthesia recovery time was significantly shorter in the remimazolam group than in the propofol group[3(3)min vs.9(4)min,P＜0.001].Conclusion Compared to propofol anesthesia,remimazolam does not increase the incidence of PONV in patients undergoing P-ESWL for pancreatic stones and can effectively reduce anesthesia recovery time.
