DiaSphere embolized microsphere TACE for treating primary hepatocellular carcinoma:A prospective multicenter randomized controlled study
10.13929/j.issn.1672-8475.2025.06.002
- VernacularTitle:DiaSphere栓塞微球TACE治疗原发性肝细胞癌:前瞻性多中心随机对照研究
- Author:
Hang YAO
1
;
Hongtao HU
;
Huicun CAO
;
Xinwei HAN
;
Jian ZHANG
;
Weifu LYU
;
Huanzhang NIU
;
Hongyuan LIANG
;
Hao XU
;
Wentao LI
;
Wei ZHAO
;
Haibo CHE
;
Yinghua ZOU
Author Information
1. 北京大学第一医院介入血管外科,北京 100034
- Publication Type:Journal Article
- Keywords:
liver neoplasms;
chemoembolization,therapeutic;
DiaSphere microspheres;
prospective studies
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(6):375-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effectiveness and safety of DiaSphere embolized microsphere TACE for treating primary hepatocellular carcinoma(HCC).Methods Totally 188 patients with HCC were prospectively enrolled and randomly assigned to research group(n=93)and control group(n=95),who underwent TACE with DiaSphere embolized microspheres and Embosphere embolized microspheres,respectively.The incidence of TACE-related adverse events were recorded.The therapeutic efficacy 1 month after the first TACE,also 1 and 3 months after the last TACE,and liver functions 1 month after the first and last TACE were compared between groups.Results In research group,there were 69 cases underwent 1 time TACE,22 cases underwent 2 times and 2 cases underwent 3 times TACE,while in control group,there were 82 cases underwent 1 time and 13 cases underwent 2 times TACE,respectively.No statistical difference of the incidence of adverse events was found between groups(77.42%[72/93]vs.76.84%[73/95],P=1.000).One month after the first TACE,7 cases in research group and 11 cases in control group were lost to follow-up,respectively.One month after the last TACE,12 cases were lost to follow-up in both groups,and 3 months after the last TACE,28 cases were lost to follow-up in both groups.No significant difference of objective response rate nor disease control rate was found between groups at the above time points(all P＞0.05).One month after the first and last TACE,liver function indicators were not different between groups(all P＞0.05).Conclusion Both the short-term efficacy and safety of TACE with DiaSphere embolized microspheres for treating HCC were good.
