Progress in targeted therapy of autoimmune encephalitisb
10.3969/j.issn.1002-0152.2025.10.007
- VernacularTitle:自身免疫性脑炎靶向治疗进展
- Author:
Yajing LIU
1
;
Zhijiao SONG
1
;
Shuanghao FENG
1
;
Hui BU
1
Author Information
1. 河北医科大学第二医院神经内科(石家庄 050000)
- Publication Type:Journal Article
- Keywords:
Autoimmune encephalitis;
Targeted therapy;
Immunotherapy;
Monoclonal antibody;
Molecular mechanism
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(10):618-626
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune encephalitis(AE)generally refers to a group of encephalitides mediated by autoimmune mechanisms.The current treatment for AE relies on immunotherapy,typically following a stepwise escalation regimen.A minority of patients may still be refractory to treatment,thus posing a major clinical challenge.In the pathogenesis of AE,B cells play a role through antibody secretion and cytokine regulation,whereas T cells contribute by promoting B cell differentiation and mediating neuronal attack.In recent years,immunotherapies targeting different antigens have become a research focus and emerged as a new treatment option for AE patients.This article summarizes the mechanisms of action of different targeted drugs and the progress of their clinical application in AE,and provides an outlook on future research directions.
