Progress in the biomarkers of insomnia comorbid with anxiety and/or depression
10.3969/j.issn.1002-0152.2025.10.010
- VernacularTitle:失眠共病焦虑抑郁生物标志物研究进展
- Author:
Qiang ZONG
1
;
Mengling ZHA
;
Xinyan ZHANG
;
Yangyang SHEN
;
Junying ZHOU
Author Information
1. 四川大学华西医院神经内科(成都 610041)
- Publication Type:Journal Article
- Keywords:
Insomnia;
Anxiety;
Depression;
Comorbidity;
Biomarkers
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(10):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Insomnia is often comorbid with anxiety and/or depression.Identifying biomarkers for this comorbidity is crucial for precise diagnosis,elucidating the underlying pathological mechanisms,and developing personalized treatment strategies.Current research has preliminarily revealed a series of potential biomarkers for insomnia comorbid with anxiety and/or depression.Elevated peripheral pro-inflammatory factors(e.g.,interleukin-6),and decreased peripheral brain-derived neurotrophic factor,and monoamine neurotransmitters(e.g.,5-hydroxytryptamine)may indicate the presence of a comorbid state.However,studies focusing on this comorbidity remain relatively limited.In the future,it will be necessary to systematically explore and verify the clinical application value of potential biomarkers through measures such as expanding sample size,strengthening longitudinal design,and expanding the categories of biomarkers.This will provide a more solid theoretical foundation for the early diagnosis and personalized treatment of insomnia comorbid with anxiety and/or depression.
