Changes of blood cell counts and hepatic and splenic fibrosis rates in rat models of liver cirrhosis and portal hypertension after partial splenic artery embolization
10.13929/j.issn.1672-8475.2025.06.008
- VernacularTitle:肝硬化伴门静脉高压大鼠模型经部分脾动脉栓塞后血细胞计数及肝脾纤维化率改变
- Author:
Zhifu TIAN
1
;
Jihong HU
1
;
Cheng WAN
1
;
Bin TAN
1
;
Wenqiu PAN
1
;
Yubo ZHANG
1
Author Information
1. 昆明医科大学第一附属医院介入科,云南 昆明 650032
- Publication Type:Journal Article
- Keywords:
rats;
liver cirrhosis,experimental;
hypersplenism;
embolization,therapeutic;
splenic artery
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(6):405-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore changes of blood cell counts and hepatic and splenic fibrosis rates in rat models of liver cirrhosis and portal hypertension after partial splenic artery embolization(PSE).Methods Fifteen rat models of liver cirrhosis and portal hypertension were successfully established.Red blood cell(RBC),white blood cell(WBC)and platelet(PLT)counts were measured.Splenic artery angiography and PSE were performed in 10 rats(PSE group),while only splenic artery angiography was performed in the rest 5 rats(control group).1 week after interventions,RBC,WBC and PLT counts were remeasured,and then the rats were euthanized to obtain liver and spleen specimens for pathological examination and evaluation of fibrosis rate.The changes of blood cell count within 1 week and the hepatic and splenic fibrosis rates 1 week after intervention were compared between groups.Results Rats in both groups exhibited good general condition within 1 week after intervention.One week after intervention,RBC,WBC and PLT counts in PSE group were all significantly higher than those before intervention(all P＜0.05),and the increasing rate of RBC,WBC and PLT counts in PSE group were larger than those in control group(all P＜0.05).WBC and PLT counts in PSE group 1 week after intervention were all higher than those in control group(both P＜0.05),but no significant difference of RBC count was observed between groups(P＞0.05).One week after intervention,hepatic fibrosis rate was higher,while splenic fibrosis rate was lower in PSE group than that in control group(both P＜0.05).Conclusion PSE might be used to improve decrease of blood cell count caused by hypersplenism in rat with liver cirrhosis and portal hypertension,hence reverse or slow down progression of splenic fibrosis.
