Correlation between skin temperature variation trajectories and radiation dermatitis in breast cancer patients undergoing radiotherapy
10.3760/cma.j.cn113030-20240727-00290
- VernacularTitle:乳腺癌放疗患者皮肤温度变化轨迹与放射性皮炎的相关性
- Author:
Yanhong ZHOU
1
;
Wenhui GENG
1
;
Junpu YIN
1
;
Lei HAN
1
;
Yuanyuan ZHANG
1
;
Wentong YANG
1
Author Information
1. 河北医科大学第四医院放疗科，石家庄 050000
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Skin temperature trajectory;
Acute radiation dermatitis;
Correlation
- From:
Chinese Journal of Radiation Oncology
2025;34(5):446-452
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between the skin temperature variation trajectory in the radiation field and the occurrence of grade 2 or higher radiation dermatitis in female breast cancer patients during postoperative radiotherapy.Methods:This prospective cohort study used convenience sampling to select 103 breast cancer patients who underwent modified radical mastectomy and subsequent radiotherapy at the Fourth Hospital of Hebei Medical University from May 2022 to December 2022. All patients received three-dimensional conformal radiotherapy (3D-CRT), with an irradiation field covering the chest wall ± supraclavicular and infraclavicular lymphatic drainage regions, and a prescribed dose of 50 Gy delivered in 25 fractions. Skin temperature in the irradiated area was measured using an infrared thermometer before radiotherapy and on the days of the 5 th, 10 th, 15 th, 20 th, and 25 th fractions. The latent classes of skin temperature variation trajectories were identified using the Mplus latent class growth model, and logistic regression was applied to analyze the correlation between the skin temperature variation trajectory and the occurrence of grade 2 or higher radiation dermatitis. Results:The skin temperature variation trajectories in the irradiated field of breast cancer patients undergoing postoperative radiotherapy could be divided into two groups: the temperature non-increasing group (81/103) and the temperature increasing group (22/103). The Akaike information criterion (AIC) was 66.468, the Bayesian information criterion (BIC) was 116.528, and the entropy was 0.810, with a likelihood ratio test P-value of 0.037, and a Bootstrap-based likelihood ratio test P-value<0.001. After adjusting for covariates such as age and body mass index, logistic regression analysis showed that the risk of developing grade 2 or higher radiation dermatitis in the temperature increasing group was 6.92 times of that in the temperature non-increasing group ( OR=6.92, 95% CI = 2.30-20.82, P=0.001). Conclusions:There is group heterogeneity in the skin temperature variation trajectories of breast cancer patients undergoing radiotherapy, and patients with a rise in skin temperature have a higher risk of developing grade 2 or higher acute radiation dermatitis.
