Association between thyroid cancer and Hashimoto thyroiditis in children and adolescents
10.12007/j.issn.0258-4646.2025.06.001
- VernacularTitle:儿童及青少年甲状腺癌与桥本甲状腺炎的相关性
- Author:
Xinhua LI
1
;
Zhihong WANG
1
;
Hao ZHANG
1
Author Information
1. 中国医科大学附属第一医院甲状腺外科,沈阳 110001
- Publication Type:Journal Article
- Keywords:
Hashimoto thyroiditis;
thyroid cancer;
children and adolescents;
research progress
- From:
Journal of China Medical University
2025;54(6):481-485
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of thyroid cancer(TC)and Hashimoto thyroiditis(HT)in children and adolescents has increased in recent years.However,the correlation between them remains unresolved.Although HT may promote the development of TC,the underlying mecha-nisms are not yet fully understood.Current hypotheses include the role of an elevated thyroid-stimulating hormone level,shared genetic alterations,and inflammation-induced changes in the tumor immune microenvironment.In addition,the clinicopathological characteristics and prognosis of patients with TC coexisting with HT differ from those of patients with TC alone.Given the significant clinicopathological differences between pediatric and adult TC,the relationship between HT and TC in the pediatric patient cohort remains unclear.This review summarizes recent research progress on the epidemiological characteristics,pathogenesis,pathological features,and prognosis of TC associated with HT in children and adolescents,providing insights for future studies in this field.
