Research progress on the influence of microRNA on the radiosensitivity of colorectal cancer
10.3760/cma.j.cn113030-20240528-00210
- VernacularTitle:微RNA对结直肠癌放射敏感性影响的研究进展
- Author:
Ruixue SUN
1
;
Jiajia WANG
1
;
Yunfeng HU
1
Author Information
1. 延安大学附属医院放射治疗科，延安 716000
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
MicroRNAs;
Radiosensitivity
- From:
Chinese Journal of Radiation Oncology
2025;34(4):395-400
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer (CRC) is one of the common gastrointestinal tumors, and radiotherapy is an important treatment modality for CRC. Increased radioresistance in tumors can lead to recurrence and poor prognosis. MicroRNAs (miRNAs) are naturally occurring small non-coding RNAs whose expression patterns are associated with clinical variables such as tumor type and stage, exhibiting significant oncogenic or tumor-suppressive functions. miRNAs regulate tumor biological functions, such as proliferation, apoptosis, invasion/metastasis, and angiogenesis, at the post-transcriptional level, either directly or indirectly. Radiotherapy, which utilizes ionizing radiation (IR) to induce DNA damage, is a molecular event mainly involving the activation of intracellular signaling pathways and post-translational modification of proteins. Mutiple studies have demonstrated that miRNAs can counteract radioresistance in CRC by regulating IR-induced DNA damage, programmed cell death, exosomes, and the generation of tumor stem cells, potentially optimizing CRC treatment. This review summarizes the research progress on the role of miRNAs in radiosensitivity in CRC, aiming to provide new therapeutic insights and approaches for CRC patients.
