Research progress in epigenetic modification in renal damage caused by hyperhomocysteinemia
10.3969/j.issn.1671-7856.2025.05.010
- VernacularTitle:表观遗传修饰在HHcy引起的肾功能损伤中的研究进展
- Author:
Yuzhen JIE
1
;
Ning DING
;
Guanjun LU
;
Shengchao MA
Author Information
1. 海南医科大学临床医学院,海口 571199;海南医科大学附属海南医院泌尿外科,海口 570311
- Publication Type:Journal Article
- Keywords:
homocysteine;
DNA methylation;
histone modification;
non-coding RNA regulation;
chronic kidney disease
- From:
Chinese Journal of Comparative Medicine
2025;35(5):95-101
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease(CKD)comprises a group of clinical syndromes affecting kidney structure and function,with various causes,high treatment costs,and a poor prognosis.Epigenetic modification of gene expression and cell function has been shown to play a key regulatory role in the occurrence and development of CKD.Homocysteine(Hey)is a common amino acid-containing thiol group in the body.Hyperhomocysteinemia(HHcy)is a damaging condition involving many organs,and is an independent predictor of end-stage renal disease morbidity and mortality.This review considers the relationship between HHcy and chronic renal injury,and examines research progress in the role of epigenetic modification in the mechanism of Hcy-mediated chronic renal injury,with the aim of furthering our understanding of the occurrence and development of CKD.This process and its mechanism provide new ideas and a theoretical basis for further research into CKD.
